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2A, 2B, 3A & 3B,R

The Journal of Sports Medicine and Physical Fitness, 59 (4), 608-612

However, excessive cytokine release can lead to a massive inflammatory cascade, which causes reversible or irreversible organ dysfunction and even death (73)

Therefore, it would be challenging to deliver an effective therapeutic concentration through the nostrils as the intranasal dosing volume may be a rate-limiting factor compared to traditional routes