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NF-B activation mediated by ER stress is dependent on Ca 2+ efflux and subsequent production of reactive oxygen species (ROS) ( The NF-B and ER stress in atherosclerosis Three stages of atherosclerosis progression Atherosclerosis is a common chronic inflammatory disease characterized by the accumulation of fibrin and lipids in subendothelial space, being a leading cause of cardiovascular diseases, including heart failure, stroke, and claudication ( Loss of intact endothelial functions occurs at the earliest in atherogenesis, followed by lipid accumulation and fatty streak formation under the endothelial cells

Iron is typically stored and transported as ferric iron (Fe 3+ ), and cells uptake iron through transferrin-dependent or transferrin-independent pathways (Johnsen et al., 2019)

[220] In 2024, she placed fourth, with her brand value rising to US$116.4 million

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Lew M (2007)