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One powerful and commonly used approach is to tag your protein of interest with Glutathione S-Transferase (GST) and perform a GST pull-down to see what binds to the protein of interest

Thus, several studies have reported a link between hippocampal synaptic decline, cognitive impairment and increased risk of neurodegeneration after OVX in animal models and menopause in women (Morrison et al., 2006

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This action can be expressed in its weak agonist activity with GABA receptors