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However, several challenges remain, including the black box nature of AI systems (such as issues of model interpretability and liability in AI-assisted diagnosis), reliance on high-quality annotated data, limited generalizability across real-world clinical settings (including model performance stability across novel scenarios, devices, diverse populations, and disease stages), and the potential for algorithmic bias (leading to diagnostic disparities due to overrepresentation of certain demographic groups in training data)

Studies demonstrate that periodic administration in aged animal models extends healthspan, improving physical performance, organ function, and resistance to age-related diseases (2, 3)

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5 Mechanisms of radiotherapy resistance in CRC 5.1 DNA damage repair CRC tumor cells have been shown to display radioresistance from multiple mechanisms such as increased DNA damage repair and escape from apoptosis