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Expression of class Pi glutathione transferase in human malignant melanoma cells

When iron levels are excessively high, the RANKL/OPG ratio increases, leading to the promotion of osteoclast maturation and bone resorption through TFR1-mediated iron uptake ( Figure 2 )

3.5.4 Gut microbiota-based therapeutic interventions 3.5.4.1 Probiotics Given these findings, probiotic supplementation, particularly with strains of Lactobacillus and Bifidobacterium , has shown potential to restore microbial balance, enhance SCFA production, and reduce inflammation in CFS/ME patients (Carrasco-Querol et al., 2024