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5-Amino-1MQ in Muscle Regeneration and Metabolic Health. Muscle & Nerve , 61(4), 455-463

The same logic applies to weight loss

NNMT (nicotinamide N-methyltransferase) is upregulated in adipose tissue during obesity and metabolic dysfunction, where it actively depletes NAD+ by converting nicotinamide into N-methyl-nicotinamide for excretion