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The genuine human Phase II trials used full-length thymosin beta-4 as a topical eye drop for dry eye, and even those had mixed results on their primary endpoints

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Can J Neurol Sci 47:336343 Karsten J, Hagenauw LA, Kamphuis J, Lancel M (2017) Low doses of mirtazapine or quetiapine for transient insomnia: a randomised, double-blind, cross-over, placebo-controlled trial

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Tolentino notes that more research is needed on this one