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It is due to the inactivation of the glutathione (GSH)-dependent antioxidant defense mechanism in cells, and the ability of GPX4 to suppress lipid ROS accumulation is inhibited, which eventually leads to lipid peroxidation and cell death (Dixon et al., 2012)

In a digestion experiment, AM silage with three levels of 5%, 10%, and 15% non-edible dates was evaluated as the sole ration component for sheep, assessing dry matter (DM) intake and digestibility coefficients of DM, organic matter (OM), crude protein (CP), and calcium in AM silage [30]

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A phase 3 double-blind, double-dummy, randomised controlled trial (RCT) comparing IPX203 with immediate-release (IR) LD/CD showed a statistically significantly greater increase in daily ON-time of + 0.53 h, and this difference was achieved with a mean of 3 daily doses vs 5 in the IR LD/CD arm [22]

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