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IL-4 exacerbates anaphylaxis

It also increases blood and oxygen supply to the heart and slows electrical activity to control heart rate

Denny MF, Atchison WD (1994) Methylmercury-induced elevations in intra-synaptosomal zinc concentrations: a 19F-NMR study

16,17,18 However, hypoxia inhibits the hydroxylation of HIF-1, causing its accumulation in the nucleus where it binds to HIF-1 and initiates transcription of hypoxia-related genes such as vascular endothelial growth factor (VEGF)