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Finally, this relatively 'coarse-grained' mode of regulation is insufficient to precisely govern the bidirectional functions of ATF members or their heterodimeric interactions, limiting its ability to achieve fine-tuned control over their specific physiological and pathological activities

(ii) counteract hyperinflammation caused by cytokine storm/inflammasome 482,483

While safe at therapeutic doses of up to 4 grams per day for adults, acetaminophen overdoses, either accidental or intentional, are the leading cause of acute liver failure in the United States, accounting for some 56,000 emergency room visits, 2,600 hospitalizations and nearly 500 deaths annually[2, 3]