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10.1016/j.metabol.2008.12.003 63

Ferrucci et al., According to the American Federation for Aging Research ( predict remaining life expectancy better than chronological age, monitor mechanisms underlying the aging process but not a specific disease, be subject to repeated tests without harming the individual, be testable in both laboratory animals and humans

Nonetheless, further experiments, for example in ovariectomized animals supplemented with or without E2, would be required to investigate this

Many intrinsic and extrinsic factors, such as neurotrophic factors, transcription factors, cell cycle regulators, cell proliferation, neurogenic niche and differentiation into mature neurons, play an important role in the pathomechanism of AD