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As a key limbic region involved in HPA-axis feedback regulation, the hippocampus indirectly modulates hypothalamic CRH neuron activity through GR- and MR-related regulatory pathways, thereby contributing to neuroendocrine homeostasis during long-term adaptation to stress ( 5 Alterations in the hippocampus due to chronic stress A large body of evidence has consistently shown that stress can markedly alter hippocampal structure and function and thereby impair hippocampus-dependent memory (Zhang et al., 2020

doi: 10.1016/j.freeradbiomed.2016.02.028 13