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The eye is extremely vulnerable to oxidative stress

Experimental studies have also demonstrated that curcumins neuroprotective efficacy in PD is associated with activation of PI3K/Akt, reduction of pro-oxidative stress markers and preservation of neuronal function, underpinning its role in delaying disease progression (Nebrisi, 2021)

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The strong GSH efflux induced by verapamil is energy dependent since MRP1 K1333L, a mutant with a defective ATPase activity, is unable to confer CS in cells overexpressing it 12

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