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This ratio (1.66) was used to calculate the overall number of genes that affect GHK at various cutoff points (rather than probe sets)

For drugs that are highly susceptible to first-pass metabolism, such as nitroglycerin, lidocaine, and propranolol, only a small fraction of the oral dose may reach the systemic circulation unchanged

Zamagni, G

L.ChinM.Christ-SchmidtH.et al (2013)

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