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Ann Indian Acad Neurol

Estudios en modelos animales sugieren efectos ansiolticos y antidepresivos, posiblemente mediados por la interaccin con los sistemas dopaminrgico y serotoninrgico

BMJ 324:15125, PMID: 12077044 Passeri M, Cucinotta D, Abate G, Senin U, Ventura A, Stramba BM, Diana R, La Greca P, Le Grazie C (1993) Oral 5-methyltetrahydrofolic acid in senile organic mental disorders with depression: results of a double-blind multicenter study

Stress-inflammatory/oxidative pathway activation results in increased transforming growth factor- (TGF-) signaling, which activates SMAD3 and increased NADPH Oxidase 2(NOX2) expression and activity at the RyR2 channel, leading to oxidation and calstabin 2 depletion from the channel macromolecular complex