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Non-canonical ubiquitination and SUMOylation in NDDs In addition to canonical K48-linked ubiquitination that targets proteins for proteasomal degradation, alternative ubiquitin chain architectures and ubiquitin-like modifications play critical roles in neuronal signaling and survival (Fig

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Some cases of vulvodynia are idiopathic where no particular cause can be determined Vestibulodynia, or simply vulvar vestibulitis is vulvodynia localized to the vestibular region