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Acknowledgements This work was supported by Ministero dellIstruzione, dellUniversit e della Ricerca of Italy, Progetto PONRicerca e Competitivit 20072013PON01_01802: Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redoxsensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e loro delivery mediante piattaforme nano tecnologiche, and PON01_02512: Ricerca e sviluppo di bioregolatori attivi sui meccanismi epigenetici dei processi infiammatori nelle malattie croniche e degenerative

Amyloid-containing deposits did not overlap with cell nuclei suggesting that these deposits are located outside infiltrating (immune) cells

Free radicals are highly reactive molecules that damage cellular structures and contribute to the development of various diseases, including cancer, heart disease, and ageing

In overall analysis, genetic associations with type 2 diabetes were obtained from DIAGRAM [32] (Additional file 1: Table S1)

Endocrinol Diabetes Metab J 1:1 Graham SF, Rey NL, Yilmaz A, Kumar P, Madaj Z, Maddens M, Bahado-Singh RO, Becker K, Schulz E, Meyerdirk LK, Steiner JA, Ma J, Brundin P (2018) Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinsons disease reveals distinct metabolic profiles