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Enhancing CPT1A activity preserves mitochondrial functions and suppresses NLRP3/GSDMD-mediated pancreatic acinar cell pyroptosis, highlighting CPT1A as a potential therapeutic target

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Subjects were excluded from l-carnitine or BB challenge testing if they were pregnant, had chronic illness (including a known history of heart failure, renal failure, pulmonary disease, gastrointestinal disorders, or hematologic diseases), had an active infection, received antibiotics within 2 months of study enrollment, used any over-the-counter or prescription probiotic or bowel-cleansing preparation within the past 2 months, ingested yogurt within the past 7 days, or had undergone bariatric or other intestinal (e.g., bowel resection/reconstruction) surgery