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Yasutake et al., 2006)

Clinical observations of primary and recurrent tumors studied over a long period highlighted the four types of tumor resistance: type 1 (melanoma), type-2, type-3 and type IV (GBM)

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Dihydrocodeine concentrations at the effect site were obtained by convolution of a first-order transfer function with the function describing the plasma concentration versus time courses, and miotic effects were related to effect-site concentrations by a sigmoidal pharmacodynamic model