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This IGF-1 independence is the single most important experimental advantage of the AOD 9604 10mg research compound for researchers designing metabolic studies: the absence of IGF-1 elevation means that downstream anabolic, mitogenic, or glucose-modulating confounds associated with full-length hGH are not present in AOD-9604 experimental models

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Although I do wonder how developers will define and measure meaningful clinical endpoints for cartilage regeneration, given the systemic versus local delivery routes and the transition from animal models to human trials

Diabetologia 66 , 17651779 (2023)

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