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Omaveloxolone was therefore specifically synthesized and pharmacologically optimized to eliminate this fluid-retaining liability while maintaining target selectivity, making it suited for the highly vulnerable cardiac and neurological landscape of FRDA [108,112]

Several studies have shown that low IGF-1 levels are associated with AD (Table 1)

This distinction has some implications for our model

Injections bypass the gut, ensuring the body utilizes the full dose

[] Increased activity of microglial cells (inflammatory processes, phagocytosis, disruption of the bloodbrain barrier and increased synthesis of oestrogen) was linked to increased ROS and unstable behaviours in mice