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Rats with an occluded superior mesenteric vein and artery may quickly experience a lack of circulation, as has been seen in rats with inferior caval vein syndrome, Pringle manoeuvre ischemia/reperfusion, and BuddChiari syndrome [5,6,7]

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Its important for researchers to note that during initial phases of exploring GHK-Cu, an observed phenomenon sometimes referred to as purging or a temporary worsening of skin condition may occur

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