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ACTH-and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors

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Although high peripheral exposure may be required to obtain the fractional central exposure necessary to illicit a pharmacologic response, insufficient selectivity between MC1R and MC4R activity can lead to peripheral activation of MC1R (26, 55, 57)

Neurofibromatosis type 1, a syndrome caused by mutations in the NF1 gene, is the major risk factor for the development of these tumors

Although the precise intracellular signaling cascades remain incompletely understood, current data suggest that receptor interactions might lead to the elevated synthesis of eumelanin