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In comparison to skeletal muscles, only a small amount of total creatine is found in the brain, however, the brain is an energetically demanding organ and accounts for approximately 20% of body energy consumption despite accounting for only 2% of total body mass (Forbes et al., 2022)

Subsequent studies have found that the mineral selenium is essential for GPX1 activity (Seale et al., 2020)

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) provided funds for research in the lab of Bruce Morgan through the grant MO 2774/61 project number 505680640

Graphical Abstract Similar content being viewed by others Introduction In less than two decades since Yamanaka and colleagues first published a protocol to reprogram somatic cells back to a pluripotent state using key transcription factors such as Oct4, Sox2, Klf4, and c-Myc, the field of human induced pluripotent stem cells (hiPSCs) has undergone remarkable advancements [1, 2]

Wet skin can cause stinging during injection