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The bioactive natural product T1 , bis(4-hydroxybenzyl)sulfide, with the most striking inhibitory potency against tyrosinase, was chosen as the target compound to characterize its biological effects in tyrosinase inhibition, cell viability, in vitro and in vivo melanin biosynthesis and acute oral toxicity in mice

Second-generation peptides incorporating chemical modifications to enhance stability, selectivity, and potency are under development

10.1021/ja400280f 32 LiuY.WuH.LiM.YinJ

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