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The combination treatment of Tamarindus indica seeds extract with the tamoxifen (TMX) eliminates the cytotoxic effect in MCF-7 cells [27]

Indeed, loss of glutathione peroxidase 4, a oxidation-resistant selenoprotein that utilizes GSH, leads to lipid peroxidation and subsequent ferroptosis, which is also found in epilepsy models ( The NADPH oxidase (NOX) family of enzymes is another relevant major source of ROS in the context of epilepsy as evidenced by activation of NOX2 by kainate-induced SE (Patel et al., 2005)

Metabotropic Glutamate Receptors Glutamate can also activate a type of G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs)

Smith AG, Singleton JR