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Ethics declarations Competing interests SGP is funded by Health Institute Carlos III (ISCIII) with a Juan Rodes contract (JR20/00033)

Statements Author contributions XF: Writing original draft, Writing review & editing

Testosterone is a sex hormone that helps to regulate sex drive, the production of red blood cells and sperm, bone mass, muscle mass and strength and fat distribution

Cuproptosis, discovered in recent years, is a novel type of programmed cell death triggered by the accumulation of excessive copper ions in mitochondria

The finding that younger people with COVID-19 also are glutathione deficient and have elevated oxidative stress and oxidant damage is really surprising, because we do not normally see these defects in younger age groups