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Measured GPX activities in the plasma (GPX3) or blood cells (GPX1 and GPX4) can be used as better biomarkers of the functional Se status

The data suggested that release of the cysteine moiety of GSH is critical for the restoration of transcriptional response to cystine starvation, which corroborated the signaling result of p-GCN, p-eIF2 and notably ATF4, which induces the expression of genes containing AARE (Fig

146,147 UC patients have been shown to have significantly diminished gut microbiota diversity, with an increase in the abundance of harmful bacteria and a decrease in the abundance of beneficial bacteria, which affects the immune regulation and inflammatory response of the gut, thereby exacerbating symptoms and promoting the progression of the disease

RS brain does not display obvious manifestations of structural neuronal or glial damage [370, 371]

Zhao, M., Yang, B., Wang, J., et al