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There are indications of effects on certain biomarkers, but results are context-dependent

The experiment demonstrates the potential of IGF-I treatment of catabolic states and especially the value of modified forms of growth factors that bind weakly to IGF-binding proteins. In another study in the Journal of Developmental Cell , IGF-1 LR3 was shown to help prevent muscle wasting and stimulate muscle growth through the activation of the IGF1R/IRS1/PI3K/Akt pathway

For example, KRAS mutations are common in several types of cancer and are linked to the activation of the MAPK pathway, making them potential biomarkers for selecting patients for ERK1/2-targeted therapies (Hong et al., 2023[51])

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