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As we age, stomach acid production can decline (atrophic gastritis), which makes it harder to extract B12 from food or pills

GHK-Cu stimulates the release of several growth factors: VEGF (vascular endothelial growth factor) for blood vessel formation, FGF (fibroblast growth factor), NGF (nerve growth factor), and BMP-2 (bone morphogenetic protein 2) (Pickart et al., 2015)

First, hyperhomocysteinemia detected only in the fasting state (approximately 23% of patients), which might mainly result from an inhibition of the homocysteine remethylation pathway (folate, cobalamin, or functional methionine synthase deficiencies or thermolabile MTHFR mutation), and which increases the cardiovascular risk 1.6-fold

In UK primary care, patients with a B12 above 1,000 pmol/L had a one-year cancer incidence rate ratio of 4.72 compared with those in the reference range

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