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In addition, the expression of Kir4.1 may be mediated by the N-methyl-D-aspartate receptor (NMDAR) expressed on astrocytes

These findings suggested that GA exhibited antihypertensive and antifibrotic effects, highlighting its significant potential for clinical translation (Choi et al., 2018)

74 Apart from tumors with mutant IDH1/2, increased 2-HG have also been reported in breast cancer 75 and renal cancer (L-enantiomer), 76 which is associated with activation of MYC and L-2-hydroxyglutarate dehydrogenase (L2HGDG) deficiency, respectively