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These results imply age-related AF is associated with its own unique metabolomic profile, which is distinct from early-onset AF and not due to aging per se

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In response to inflammation and OxS, the activated HO-1 is a powerful down-regulator of pro-coagulant factors to prevent thrombotic events, endothelial injury from vascular inflammation, resolve FeRD and reset HMRD in COVID-19 and PASC patients 27,46

Notably, the suppression of gene sets associated with DNA replication and repair does not indicate increased genotoxic stress, but rather reflects a regulated downshift of proliferative programs

Aye S, Johansson G, Hock C et al (2025) Point of view: challenges in implementation of new immunotherapies for Alzheimers disease