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Figure 3 Long-lasting nuclear occupancy of RelA increases the chances that significant numbers of NF-B dimers are present in the nucleus when B sites become available for binding, while also allowing time for other signaling pathways and transcription factors to modulate chromatin accessibility, tailoring the response to a particular stimulus or group of stimuli

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Subsequent animal studies have shown that mitochondrial heterogeneity can lead to a metabolic syndrome-like phenotype and adversely affect cognitive function