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This complexity suggests that altered estrogen signaling may represent a key mechanistic pathway linking NSW to BC risk and warrants further investigation considering individual circadian profiles and shift patterns

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Similarly, melatonin has been demonstrated to upregulate GDNF in neural stem cells (Li et al., 2017), and in the C6 glioma cell line (Heermann et al., 2012) or their precursors (Cornejo et al., 2010)

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