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The number of intravitreal injections performed annually in the United States rose from less than 3000 in 1999 to more than 1 million in 2008, 1 and it is estimated that more than 7 million intravitreal injections will be performed in the United States in 2017

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its expression varies depending on the stimulus

Interestingly, Fer-1-treated monocytes displayed significantly lower frequency of cells expressing pro-IL-1 which was not seen in cultures treated with MCC950 ( Figure 6C ), consistent with its effect downstream of the signal 2 for NLRP3 activation