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Next, clinical trials can be initiated for proof-of-concept validation

From 8 trials, three followed a cross-over design [2325]

J Cell Physiol

L-carnitine may provide mild benefits without exercise, but its fat-burning and energy-boosting effects are significantly stronger when combined with regular physical activity and a healthy diet

Our results show that the detected longevity-associated SNPs could also serve as potential markers of diseases." In a July 2025 abstract, the team that published the September 2011 article (below), in which they identified regions on chromosome (CFA) 13 and 14 associated with early onset MVD in cavaliers, reported identifying variants in the incRNA and in LMOD2 to be only in cavaliers