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In summary, long-term mTORC1 inhibitor treatment with rapamycin led to an RP phenotype, with broad chromatin, expression, and metabolic rewiring in comparison with the starting mTORC1-activated cell lines

Next, GS-4997, a specific ASK1 inhibitor, was used to confirm that the expression of SREBF1 and PLIN2 is regulated by ASK1-p38/JNK signalling

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220, 272 Multiplex genotyping studies During the last decade, dozens of studies have been carried out to determine whether SNPs affecting one or more genetic loci would influence the natural course of multiple neoplasms (leading to the identification of prognostic biomarkers) or the propensity of neoplastic lesions to respond to specific therapeutic regimens, including CDDP-based chemotherapy (resulting in the characterization of predictive biomarkers)