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Endotoxemia Lipopolysaccharide (LPS) is a major component of the outer membrane of all gram-negative bacteria that can trigger the synthesis and release of pro-inflammatory cytokines such as TNF, interleukin 1 (IL-1), and inducible nitric oxide synthase (iNOS) (Zhang et al., 2000

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The flotation assay consisted of the incubation of PM-LUVs and LM-LUVs with -SNAP WT or M105I and the subsequent flotation (after centrifugation) of the LUVs on a sucrose gradient to separate vesicle-bound proteins from unbound proteins (Fig

An animal study (Liu et al., 2023) showed that downregulation of CLDN5 under hypoxic conditions could significantly activate the expression of ferroptosis-related genes and inhibit the expression of SLC7A11, inducing BBB disruption

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