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Increasing BHB levels before ischemia/reperfusion injury reduces infarct size in rodents, and exogenous BHB delivery can protect the heart from ischemia/reperfusion injury (I/R injury), reduce mitochondrial ROS formation, and increase ATP production

It binds to the PHB1-ANXA2 receptor complex found on blood vessels supplying white adipose tissue throughout the body

The significant 21% reduction in blood glucose levels in rats treated with blank SeNPs, compared to ~ 2045 of INS-SeNPs with insulin dose of 12.5, 25, or 50 IU/kg, demonstrated the antidiabetic properties of Se, which also contributes to this effect

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doi: 10.1016/j.humpath.2007.09.010