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Yao W, Tao R, Wang K, et al

With this in mind, the resistance of small molecule agonists or antagonists appears due to reduction of the binding affinity by mutation of target, PROTAC is likely to overcome this challenge

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Levodopa itself does little to combat oxidative stressin fact, the oxidative metabolism of dopamine (and of levodopa in peripheral tissues) can generate reactive oxygen species and toxic dopaminequinones [58]