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Macropinocytosis of extracellular glutathione ameliorates tumor necrosis factor release in activated macrophages

Additionally, metal ion metabolism disturbances are the basis for the onset of various neurological diseases [175]

Code A represents a high quality of evidence, B represents a moderate quality of evidence, C represents a low quality of evidence, and D represents a very low quality of evidence, while number 1 stands for a strong level of recommendations and number 2 stands for a weak level of recommendations

4) GPX4-independent ferroptosis suppressionDHODHCoQ10H 2 pathway in the mitochondria: Dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme localized to the mitochondrial inner membrane, catalyzes the fourth step of pyrimidine biosynthesisconverting dihydroorotate (DHO) to orotate (OA)while transferring electrons to mitochondrial ubiquinone, reducing it to CoQ10H 2 , which acts as a radical-trapping antioxidant (107)

307 (11), C1058C1067