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Another feature of cytosolic and nuclear ISC biogenesis that is similar to mitochondrial ISCs biogenesis is the dependency on a supply of electrons (Webert et al., 2014)

However, given their high evidentiary power, RCTs remain valuable for establishing causal relationships following observational studies

When cMyc is overexpressed, it leads to coordinated changes in the expression of various gene families, which collectively enhance cellular growth and division

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It is worth mentioning that a recent study found that in tumors, the metabolite lactate affected the TME by regulating the lactylation of MOESIN in Tregs and enhancing TGF- signal transduction, thus promoting a new mechanism of tumorigenesis 266