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The animal research itself shows remarkable consistency

Once stabilized, maintenance doses are typically administered every one to three months

Iron deposition in the heart can cause arrhythmias, systolic dysfunction, cardiac hypertrophy, and cardiomyopathy

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Vitamin B12 deficiency in DNA synthesis reduction is explained by the folate trapping theory as methyl-tetrahydrofolate.(...) methionine synthase cannot be activated and folate remains as methyl-FH4, which also causes a functional folate deficiency, thus explaining megaloblastic anemia." SOURCE: Interrelation of Vitamin B12 and Folic Acid