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doi: 10.1038/s41551-022-00903-4 110 ZhangL.WangY.WangJ.WangY.ChenA.WangC.et al

Researchers also point out that a seven-amino acid synthetic peptide based on the actin-binding part of TB4 was able to promote repair in the aged animals comparable to that observed with the parent molecule. The amino acid sequence noted was LKKTETQ TB-500 without the N-terminal acetylation.26 November 2011 review In a review of TB4s basic properties and clinical applications, researchers dub it a regenerative peptide due to its role in repairing injured cells and tissues

The addition of glucagon receptor agonism introduces theoretical concerns about hepatic glucose output, though no clinically significant hyperglycemia was observed