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The therapeutic effects of antidepressants consist in the increased function of the noradrenergic or serotonergic system, leading to increased activity of transcription factor CREB (cAMP response element binding protein), higher expression of neurotrophin BDNF and its receptor trkB, and consequently to increased neuronal plasticity and resumption of cellular functions

Consistently, DMF significantly induced the expression of antioxidant proteins such as Nqo1 and Gpx4, which are critical for detoxification reaction and GSH utilization (Fig