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For example, glutathione-S-tranferase gene polymorphisms confer reduced risk in pancreatic cancer (Jiao et al., 2007)

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Moreover, leptin can cross the BBB and bind to receptors in the arcuate nucleus of the hypothalamus, regulating neurotransmitters such as neuropeptide Y (NPY), cocaine-amphetamine regulated transcript (CART), serotonin (5-HT), and neuropeptide U (NPU), thereby in-directly influencing the bone-brain neural network (61)

Constant pressure leads to the neural scar effect's gradual loss of hippocampus volume

this group found that overexpression of PEA-15 inhibits tumorigenesis, reduces DNA synthesis and induces caspase-8-dependent apoptosis through increased intracellular levels of activated extracellular signal-regulated kinase