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Infection, some medications and foods with high level of convicine, vicine, divicine and isouramil such as fava beans can cause oxidative stress

Studies in cultured rat hepatocytes and perfused livers

Unraveling the complexity of STAT3 in cancer: Molecular understanding and drug discovery

Exp Toxicol Pathol 65:853861 Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB (2008) Phosphorylation of serine 68 in the IB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor--induced NF-B activity

Future multicenter studies with longer follow-up periods are needed to validate these findings and better evaluate the long-term benefits and limitations of this treatment approach