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(ii) the aforementioned predisposing role for TC (particularly, papillary TC) and its advanced stages exerted not only by HT but also by even trendwise high serum TSH levels per se (6588)

1,15 Hyperglycemia-induced metabolic pathways Polyol pathway activation In a hyperglycemic state, excess glucose is shunted into the polyol pathway, where aldose reductase catalyzes its reduction to sorbitol, which in turn is oxidized to fructose by sorbitol dehydrogenase