The defect was specific to the IL-12IFN- axis
Acetaminophen in doses above 2g/day (saturates sulfation and glucuronidation, depletes glutathione catastrophically) R Alcohol (depletes glutathione, NAD+, SAM-e, and directly damages hepatocytes) R Charcoal-grilled meats (heterocyclic amines that undergo bioactivation via sulfation and acetylation, generating DNA-reactive intermediates) R Chronic NSAID use (competes for glucuronidation and amino acid conjugation pathways) Excess fructose (depletes ATP and drives uric acid production, impairing energy-dependent conjugation) R Glyphosate residues on non-organic produce (disrupts glycine metabolism and chelates manganese) R High-dose turmeric or quercetin without cycling (both inhibit SULT1A1 and can paradoxically impair sulfation at high sustained doses) R Processed foods with benzoate preservatives (benzoic acid consumes glycine through conjugation, depleting the glycine pool for other Phase II reactions) R Proton pump inhibitors chronically (reduce magnesium absorption, impair glucuronidation) R Testing These tests can help identify which conjugation pathways are impaired and what is contributing to the dysfunction
A more recent, larger study confirmed these results, finding that the rate of isotretinoin-induced acne flaring dropped significantly from 30% in those who received isotretinoin alone down to 5% in the group that took isotretinoin plus levocetirizine 2
Note: As with any IV service, side effects can occur (e.g., bruising, discomfort at the IV site, lightheadedness, or allergic reaction)
Yabuuchi et al., 2008)
