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Even more, it has recently been postulated that the restriction of DNA synthesis to the reductive phase of the cycle in yeast may be an evolutionarily important mechanism for reducing oxidative damage to DNA during replication [51], which implies the common mechanism of the DNA protection during S phase in all eukaryotes

In addition to its protective effect in neonatal mouse models, TRX-1 also showed its protective effect in adult mouse models of COPD induced by cigarette smoke

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[DOI] [PMC free article] [PubMed] [Google Scholar] [39].Fujimoto K, Kumagai K, Ito K, Arakawa S, Ando Y, Oda S, Yamoto T, Manabe S